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Tyrosine-protein phosphatase non-receptor type 11, Rabbit Polyclonal Antibody
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Catalog Number
R-1101
- Product Name Tyrosine-protein phosphatase non-receptor type 11, Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Tyrosine-protein phosphatase non-receptor type 11 Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, IHC-Paraffin-embedded.
- Alternative Names EC 3.1.3.48; Protein-tyrosine phosphatase 2C; PTP-2C; PTP-1D; SH-PTP3; SH-PTP2; SHP-2; Shp2; PTPN11; PTP2C; SHPTP2;
- Application(s) IHC-Frozen, IHC-Paraffin-embedded, WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat;
- Species Reactivity Human, Rat
- Immunogen Description A synthetic peptide (EDSARVYENVGLMQQ) corresponding to a region (578-592) from the C-terminus of human Tyrosine-protein phosphatase non-receptor type 11. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Conjugate Unconjugated
- Purity Description Affinity purified on antigen column
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Tyrosine-protein phosphatase non-receptor type 11 Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, IHC-Paraffin-embedded.
- Application(s) IHC-Frozen, IHC-Paraffin-embedded, WB
- Application Details Immunohistochemistry (IHC) and Western Blotting (WB). A concentration of 1.0-2.0 µg/mL is recommended for WB. Human SHP2 has a predicted length of 597 residues and MW of 68 kDa. A concentration of 1.0-2.0 µg/mL is recommended to detect the protein in formalin fixed and paraffin embedded tissues. Antigen retrieval is required. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Tyrosine-protein phosphatase non-receptor type 11
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat;
- Target Host Species Human
- Species Reactivity Human, Rat
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (EDSARVYENVGLMQQ) corresponding to a region (578-592) from the C-terminus of human Tyrosine-protein phosphatase non-receptor type 11. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Purity Description Affinity purified on antigen column
- Format Lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material.
- Storage Instructions At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability.Avoid freeze-thaw cycles
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names EC 3.1.3.48; Protein-tyrosine phosphatase 2C; PTP-2C; PTP-1D; SH-PTP3; SH-PTP2; SHP-2; Shp2; PTPN11; PTP2C; SHPTP2;
- Uniprot Number Q06124
- Uniprot Number/Name Q06124 (PTN11_HUMAN)
- Scientific Background Tyrosine-protein phosphatase non-receptor type 11 (SHP2) plays a regulatory role in various cell signaling events such as mitogenic activation, metabolic control, transcription regulation and cell migration. SHP2 is highly expressed in the cytoplasm of heart, brain and skeletal muscle tissue. At least 3 isoforms of SHP2 are produced by alternative splicing.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.