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Alpha-synuclein, Sheep Polyclonal Antibody

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Catalog Number
S-078
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    Product Info

  • Product Name Alpha-synuclein, Sheep Polyclonal Antibody
  • Product Description google Sheep anti-Alpha-synuclein Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen, IHC-Paraffin-embedded.
  • Alternative Names Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
  • Application(s) IHC-Frozen, IHC-Paraffin-embedded
  • Antibody Host Sheep
  • Antibody Type Polyclonal
  • Specificity Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by western blot. This antiserum is known to react with human and rat alpha synuclein.
  • Species Reactivity Human, Rat
  • Immunogen Description A synthetic peptide (PQEGILEDMPVDPC) of human alpha synuclein protein (aa: 108-120) conjugated to diphtheria toxoid has been used as the immunogen.
  • Conjugate Unconjugated
  • Purity Description Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.
  • Regulatory Status For research use only.

    Specifications

  • Product Description Sheep anti-Alpha-synuclein Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen, IHC-Paraffin-embedded.
  • Application(s) IHC-Frozen, IHC-Paraffin-embedded
  • Application Details IHC. Recommended to be used at a concentration of 1 µg/mL for immunohistochemistry (Paraffin sections). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Alpha-synuclein
  • Specificity Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by western blot. This antiserum is known to react with human and rat alpha synuclein.
  • Target Host Species Human
  • Species Reactivity Human, Rat
  • Antibody Host Sheep
  • Antibody Type Polyclonal
  • Antibody Isotype IgG
  • Conjugate Unconjugated
  • Immunogen Description A synthetic peptide (PQEGILEDMPVDPC) of human alpha synuclein protein (aa: 108-120) conjugated to diphtheria toxoid has been used as the immunogen.
  • Purity Description Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.
  • Format Lyophilized
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
  • Uniprot Number P37840
  • Uniprot Number/Name P37840 (SYUA_HUMAN)
  • Scientific Background Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Immunohistochemical staining (paraffin-embedded tissue) of alpha synuclein in human neocortex using sheep polyclonal to human alpha synuclein, catalogue number S-078-50.

  • Immunofluorescence staining of alpha synuclein in cultured cells using Sheep antibody to alpha synuclein, catalog number S-078-50 and fluorescent-labelled secondary antibody. Image courtesy of Dr Wei-Ping Gai, Flinders University of South Australia.