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Beta-synuclein, Sheep Polyclonal Antibody
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Catalog Number
S-077
- Product Name Beta-synuclein, Sheep Polyclonal Antibody
- Product Description Sheep anti-Beta-synuclein Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen.
- Alternative Names SNCB
- Application(s) IHC-Frozen
- Antibody Host Sheep
- Antibody Type Polyclonal
- Specificity Known to be specific for beta synuclein. This antiserum is known to react with beta synuclein of human, rat and other rodents.
- Species Reactivity Human, Rat
- Immunogen Description A synthetic peptide (IEPLMEPEGSYEDPPQE) of human beta synuclein protein (aa: 108-125) conjugated to diptheria toxid has been used as the immunogen.
- Conjugate Unconjugated
- Purity Description Affinity purified
- Regulatory Status For research use only.
Product Info
- Product Description Sheep anti-Beta-synuclein Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen.
-
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- Application(s) IHC-Frozen
- Application Details IHC. A working concentration of 1 µg/mL is recommended. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Beta-synuclein
- Specificity Known to be specific for beta synuclein. This antiserum is known to react with beta synuclein of human, rat and other rodents.
- Target Host Species Human
- Species Reactivity Human, Rat
- Antibody Host Sheep
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (IEPLMEPEGSYEDPPQE) of human beta synuclein protein (aa: 108-125) conjugated to diptheria toxid has been used as the immunogen.
- Purity Description Affinity purified
- Format Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names SNCB
- Uniprot Number Q16143
- Uniprot Number/Name Q16143 (SYUB_HUMAN)
- Scientific Background Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
Specifications
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General References
Lundvig, et al Brain Res Mol Brain Res 134, 3-17 (Mar 24, 2005).
Bennett, Pharmacol Ther 105, 311-31 (Mar, 2005).
Vekrellis, et al., Mol Neurobiol 30, 1-21 (Aug, 2004).
Martin, et al., Protein Pept Lett 11, 229-37 (Jun, 2004).
Doherty, et al., Acta Neuropathol (Berl) 107, 169-75 (Feb, 2004).
Goedert, Curr Opin Genet Dev 11, 343-51 (Jun, 2001).
Saito, et al., J Neurol Sci 177, 48-59 (Aug 1, 2000).
Lucking et al. Cell Mol Life Sci. 2000 Dec;57(13-14):1894-908.
Kahle, et al., Ann N Y Acad Sci 920, 33-41 (2000).
Clayton, et al., Trends Neurosci 21, 249-54 (Jun, 1998).