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Pan-synuclein, Sheep Polyclonal Antibody
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Catalog Number
S-044
- Product Name Pan-synuclein, Sheep Polyclonal Antibody
- Product Description Sheep anti-Pan-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
- Application(s) IHC-Frozen, WB
- Antibody Host Sheep
- Antibody Type Polyclonal
- Specificity Overlap specific immunohistochemical staining of alpha-, beta- and gamma synucleins This antiserum recognises human and rat alpha-, beta- and gamma synucleins.
- Species Reactivity Human, Rat
- Immunogen Description A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid has been used as the immunogen.
- Conjugate Unconjugated
- Purity Description Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.
- Regulatory Status For research use only.
Product Info
- Product Description Sheep anti-Pan-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
-
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- Application(s) IHC-Frozen, WB
- Application Details IHC, WB. A concentration of 3 µg/mL is recommended for immunohistochemistry (frozen & paraffin embedded sections) and 1 µg/mL for western blot. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Pan-synuclein
- Specificity Overlap specific immunohistochemical staining of alpha-, beta- and gamma synucleins This antiserum recognises human and rat alpha-, beta- and gamma synucleins.
- Target Host Species Human
- Species Reactivity Human, Rat
- Antibody Host Sheep
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid has been used as the immunogen.
- Purity Description Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.
- Format Lyophilized
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Uniprot Number P37840; Q16143; O76070
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Uniprot Number/Name
P37840 (SYUA_HUMAN)
Q16143 (SYUB_HUMAN)
O76070 (SYUG_HUMAN) - Scientific Background Detects human alpha-, beta-, and gamma synuclein proteins. A family of homologous proteins known as alpha-, beta-, and gamma-synuclein are abundantly expressed in brain, especially in the presynaptic terminal of neurons. Although the precise function of these proteins remains unknown, alpha-synuclein has been implicated in synaptic plasticity associated with avian song learning as well as in the pathogenesis of Parkinson's disease (PD), dementia with LBs (DLB), some forms of Alzheimer's disease (AD), and multiple system atrophy (MSA).
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
Specifications
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General References
Lundvig, et al Brain Res Mol Brain Res 134, 3-17 (Mar 24, 2005).
Bennett, Pharmacol Ther 105, 311-31 (Mar, 2005).
Vekrellis, et al., Mol Neurobiol 30, 1-21 (Aug, 2004).
Martin, et al., Protein Pept Lett 11, 229-37 (Jun, 2004).
Doherty, et al., Acta Neuropathol (Berl) 107, 169-75 (Feb, 2004).
Goedert, Curr Opin Genet Dev 11, 343-51 (Jun, 2001).
Saito, et al., J Neurol Sci 177, 48-59 (Aug 1, 2000).
Lucking et al. Cell Mol Life Sci. 2000 Dec;57(13-14):1894-908.
Kahle, et al., Ann N Y Acad Sci 920, 33-41 (2000).
Clayton, et al., Trends Neurosci 21, 249-54 (Jun, 1998).